The Release-SCE range formula was created to give the sufficient doses of each element needed, under the safety regulations linked to the recommended safety data on each individual combination of the ingredients, to enhance and maintain the intended function, and to be safe to use over long periods of time.
False data written by an independent author was released on certain websites regarding the quality and the safety of the SSRI functionality in Sceletium ( Kanna ) unfortunately other kanna / sceletium selling companies have copied that data and shared it on their sites too.The outcome, false data contradicting itself and the clinical data they based the information on was a study conducted between SSRI’s ( selective serotonin re-uptake inhibitors ) , MAOI’s( Monoamine oxidase inhibitors) , and MDMA (Methylenedioxymethaphetamine). This study was done for a drug called Fluoxetine, a variant of Prozac – both Scheduled 4. The outcome of this study was projected as a contraindication to the SSRI element in the Sceletium Tortusuom plant for the safety there of. Unfortunately, this data was shared and created a false image of the wonderful power the Sceletium plant has. It is true that there was a lack of evidence on the safety of the natural SSRI ability in the Sceletium plant when used with scheduled SSRI’s or Neuro Recreational drugs. The recent studies on Sceletium have proven that this natural product is a rich source in therapeutic agents. It was based on the extraction, isolation, identification, and pharmacological research on the alkaloids from Sceletium tortuosum,
Sceletium tortuosum and its alkaloids can act as PDE4 and 5-TH inhibitors to improve memory and improve cognition. It acts as an anti-anxiety and anti-depressant synergist as a PDE4 and serotonin reuptake inhibitor, and also acts as a monoamine releasing agent to slightly inhibit monoamine oxidase type A activity. It regulates anxiety by regulating related hormones and produces antidepressant activity. At high doses combined with GABA and opioid receptors, it can relieve anxiety symptoms.
Sceletium tortuosum improves sleep quality by regulating the sleep-wake cycle by regulating the PDE4-cAMP-CREB signaling cascade. It also reduces pain-related δ, α2 and β1 attenuation associated θ waves to exert analgesic effects and does not produce addiction due to non-inhibition of dopamine transporter. In addition, it has a certain potential for epilepsy treatment because of its action on AMPA-mediated transmission. Pei Yu Journal of Pharmaceutical and Biomedical Sciences
Sceletium tortuosum and its pharmacological activity
VOL 10, ISSUE 06, YEAR 2020 157
Sceletium tortuosum may be involved in a variety of neurodegenerative diseases, chronic diseases, for the targeting of the central nervous system. The related pharmacological effects have been demonstrated by experiments. It has played a certain role in neurological diseases. The alkaloids of Sceletium tortuosum exerted cellular protective and anti-inflammatory effects and exhibited effective antioxidant effects to maintain the integrity of the central nervous system, which may be employed as either a preventative supplement or complimentary treatment in the context of obesity and diabetes 4.
Nowadays, people face increasing levels of stress, anxiety, insomnia and depression. Elderly people are particularly susceptible to diseases such as cognitive memory disorders, Alzheimer’s disease, vascular dementia, Parkinson’s disease and so on. Excitingly, animal and human studies of Sceletium tortuosum have showed an excellent safety profile. At the same time, preliminary human studies and clinical experience have shown its therapeutic efficacy in anxiety, depression, cognitive impairment and so on.
The conclusion is that it is never safe to just leave or change your scheduled medication without a medical practitioners opinion. The higher doses of the serotonin releasing agents might have an effect if you use Release-SCE at higher doses with your prescribed SSRI’s or any other prescribed scheduled medication. The answer would be to start substituting with a dual dose, and transferring to the more safe alternative with the help of your medical practitioner.